In Silico Approach Towards the Prediction of Drug-Likeness; Synthesis and In Vitro Evaluation of Biphenyl Derivatives
M. Irshad, S. B. Jamal, M. Faheem, M. Aslam, S. S. Shafqat, A. Kanwal
Российский журнал общей химии
https://doi.org/10.1134/S1070363221060153
Two series of biphenyl derivatives have been synthesized, characterized and evaluated for various biological activities. One of the products demonstrates efficient urease inhibition. All compounds synthesized from fast blue B salt and O-alkylated derivatives display excellent β-glucuronidase inhibition activity, and one of those is a scavenger of superoxide anion radical. The products are not active in phosphodiestrase inhibition bioassay. Most of synthetic biphenyl analogues have demonstrated significant in vitro antimalarial activity against plasmodium falciparum. All synthesized compounds exhibit low mortality effect on the tested insects. Molecular structures of the synthesized compounds have been docked into the active sites of urease and β-glucuronidase protein, and all active compounds have demonstrated good interacting pattern. Upon further experimental validation, these compounds could be used as potential inhibitors against urease and β-glucuronidase.
- Department of Chemistry, Division of Science & Technology, University of Education, 54770, Lahore, PakistanM. Irshad, M. Aslam, S. S. Shafqat & A. Kanwal
- Department of Biological Sciences, National University of Medical Sciences, The Mall, Rawalpindi, 46000, Punjab, PakistanS. B. Jamal & M. Faheem
- Olkhovik, V.K., Vasilevskii, D.A., Pap, A.A., Kalechyts, G.V., Matveienko, Y.V., Baran, A.G., Halinouski, N.A., and Petushok, V.G., Arkivoc., 2008, vol. 9, p. 69. https://doi.org/10.3998/ark.5550190.0009.908
- Madhukar, A., Kannappan, N., Deep, A., Kumar, P., Kumar, M., and Verma, P., Int. J. Chem. Tech. Res., 2009, vol. 1, p. 1376.
- Deep, A., Jain, S., Sharma, P.C., Verma, P., Kumar, M., and Dora, C.P., Acta. Pol. Pharm., 2010, vol. 67, p. 255.
- Naser, A.W., Al-Musawi, A.J., Fadhil, A.A., and Al-Shawi, N.N., Int. J. Pharm. Sci. Res., 2017, vol. 8, p. 1598. https://doi.org/10.13040/IJPSR.0975-8232.8(4).1598-05
- Shinde, M.G., Modi, S.J., and Kulkarni, V.M., J. Appl. Pharm. Sci., 2017, vol. 7, p. 37. https://doi.org/10.7324/JAPS.2017.71006
- Jaina, A., Ratnawat, S., and Chaturvedi, S.C., Iran. J. Pharm. Sci., 2010, vol. 6, p. 51.
- Makarov, V.A., Riabova, O.B., Granik, V.G., Wutzler, P., and Schmidtke, M., J. Antimicrob. Chemother., 2005, vol. 55, p. 483. https://doi.org/10.1093/jac/dki055
- Pisano, M., Pagnan, G., Loi, M., Mura, M.E., Tilocca, M.G., Palmieri, G., Fabbri, D., Dettori, M.A., Delogu, G., Ponzoni, M., and Rozzo, C., Mol. Cancer., 2007, vol. 6, p. 1. https://doi.org/10.1186/1476-4598-6-8
- Kong, X.W., Zhang, Y.H., Dai, L., Ji, H., Lai, Y.S., and Peng, S.X., Chin. Chem. Lett., 2008, vol. 19, p. 149. https://doi.org/10.1016/j.cclet.2007.11.025
- Cincinelli, R., Zwick, V., Musso, L., Zuco, V., Cesare, M.D., Zunino, F., Pires, C.S., Nurisso, A., Giannini, G., Cuendet, M., and Dallavalle, S., Eur. J. Med. Chem., 2016, vol. 112, p. 99. https://doi.org/10.1016/j.ejmech.2016.02.001
- Ali, Q., Irshad, M., and Asghar, A., Russ. J. Gen. Chem., 2018, vol. 88, p. 2177. https://doi.org/10.1134/S1070363218100249
- Biglar, M., Soltani, K., Nabati, F., Bazl, R., Mojab, F., and Amanlou, M., Iran J. Pharm. Res., 2012, vol. 11, p. 831.
- Collins, R.A., Ng, T.B., Fong, W.P., Wan, C.C., and Yeung, H.W., Biochem. Mol. Biol. Int., 1997, vol. 42, p. 1163. https://doi.org/10.1080/15216549700203631
- Gaulejac, N.S., Provost, C., and Vivas, N., J. Agric. Food Chem., 1999, vol. 47, p. 425. https://doi.org/10.1021/jf980700b
- Ziegler, H.L., Staerk, D., Christensen, J., Hviid, L., Hagerstrand, H., and Jaroszewsk, J.W., Antimicrob. Agents Chemother., 2002, vol. 46, p. 1441. https://doi.org/10.1128/AAC.46.5.1441-1446.2002
- Guo, Y., Qu, H., Zhi, X., Yu, X., Yang, C., and Xu, H., J. Agric. Food Chem., 2013, vol. 61, p. 11937. https://doi.org/10.1021/jf404195m
- Mamillapalli, R., Haimovitz, R., Ohad, M., Shinitzky, M., FEBS Lett., 1998, vol. 436, p. 256. https://doi.org/10.1016/S0014-5793(98)01142-9
- Vilar, S., Cozza, G., and Moro, S., Curr. Top. Med. Chem., 2008, vol. 8, p. 1555. https://doi.org/10.2174/156802608786786624
- Wadood, A., Riaz, M., Jamal, S.B., and Shah, M., Mol. Biol. Rep., 2014, vol. 41, p. 337. https://doi.org/10.1007/s11033-013-2867-x