Investigation of the Structure of Cyclodextrin Nitrates by the X-Ray Diffraction Method
Yu. M. Mikhailov, L. B. Romanova, M. A. Rakhimova, A. V. Darovskikh, A. E. Tarasov, D. Yu. Kovalev, A. P. Sirotina
Российский журнал прикладной химии
https://doi.org/10.1134/S1070427222010049
The structure of α-, β- and γ-cyclodextrin nitrates was analyzed by X-ray diffraction. It has been established that with an increase in the number of nitrate groups in β- and γ-cyclodextrin nitrates, the structure changes from crystalline at a degree of substitution of hydroxyl group 9–12% to amorphous at that of more than 40%, which is a consequence of steric factors and different degrees of polarity of functional groups (OH) and (ONO2). In the case of α-cyclodextrin nitrates, with an increase in the degree of substitution of OH group, the tendency to amorphization of the substance, which is characteristic of β- and γ-cyclodextrin nitrates, remains. However, at a degree of substitution of 98–100% the appearance of a new crystalline phase is observed. Probably, the molecules of α-cyclodextrin nitrates, which have only 6 glucopyranose units in their composition, undergo structural changes due to steric effects, resulting in the formation of a new molecular crystal structure with a more stable configuration.
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- Merzhanov Institute of Structural Macrokinetics and Materials Science, Russian Academy of Sciences, Chernogolovka, 142432, Moscow oblast, RussiaD. Yu. Kovalev
- Institute of Nanotechnologies of Microelectronics, Russian Academy of Sciences, 119991, Moscow, RussiaA. P. Sirotina
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