Статья
2020
Synthesis and Anticancer Activity of a Novel Series of Tetrazolo[1,5-a]quinoline Based 1,2,3-Triazole Derivatives
R. Nagaraju, K. Gopichand, N. N. Rao, A. M. Ganai, E. Kishan, P. Venkateswar Rao
Российский журнал общей химии
https://doi.org/10.1134/S1070363220020255
Abstract / Full Text
We report here the synthesis of a novel series of tetrazolo[1,5-a]quinoline based 1,2,3-triazoles from acetaniline via the Vilsmeier–Haack reaction, the Claisen–Schmidt condensation and 1,3-dipolar Click reaction. The newly synthesized compounds have been tested for their anticancer activity against a panel of three cell lines such as cervix (SiHa), brest (MDA-MB-231) and pancreatic carcinoma (PANC-1). Most of the synthesized compounds possess potent anticancer activity.
Author information
- Department of Chemistry, University College of Science, Osmania University, 500007, Hyderabad, IndiaR. Nagaraju, K. Gopichand, N. N. Rao, A. M. Ganai, E. Kishan & P. Venkateswar Rao
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