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Статья
2021

Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety


M. E. A. ElasasyM. E. A. Elasasy, D. H. ElnaggarD. H. Elnaggar, N. A. Abdel HafezN. A. Abdel Hafez, M. E. AzabM. E. Azab, A. E. AmrA. E. Amr, M. M. OmranM. M. Omran, A. M. MohamedA. M. Mohamed
Российский журнал общей химии
https://doi.org/10.1134/S1070363221050236
Abstract / Full Text

Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity. Thiazole derivatives have been synthesized by the reaction of alpha-halo carbonyl compounds with thiosemicarbazones. Some pyridine derivatives have been synthesized by the reaction of chalcone with cyanothioacetamide and/or malononitrile. Spectroscopic methods have been used for elucidating molecular structures of the products. Cytotoxic activity of several derivatives has been tested against human breast cancer (MCF-7), human colon cancer (HCT-116) and human liver cancer (Hep-G2) by the SRB method. Most of compounds exhibit mild effect on the tested cell lines. One of thiazolidin-4-one derivatives has been characterized by moderate to strong effect on MCF-7 cell line.

Author information
  • Applied Organic Chemistry Department, National Research Centre, Dokki, 12622, Giza, EgyptM. E. A. Elasasy, D. H. Elnaggar, N. A. Abdel Hafez & A. M. Mohamed
  • Chemistry Department, Faculty of Science, Ain Shams University, Abbasia, 11566, Cairo, EgyptM. E. Azab
  • Pharmaceutical Chemistry Department, Drug Exploration and Development Chair (DEDC), College of Pharmacy, King Saud University, 11451, Riyadh, Saudi ArabiaA. E. Amr
  • Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622, Cairo, EgyptA. E. Amr
  • Cancer Biology Department, Pharmacology Unit, National Cancer Institute, Cairo University, 11796, Cairo, EgyptM. M. Omran
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