Electrochemical Synthesis of 2-(2-Chlorophenyl)-2-[(3,4- dihydroxyphenyl)(methyl)amino]cyclohexanone

M. Najafi M. Najafi , M. M. Lajvardi M. M. Lajvardi , L. Youseftabar-Miri L. Youseftabar-Miri , M. Ameri M. Ameri , O. Ghaderi O. Ghaderi
Российский электрохимический журнал
Abstract / Full Text

Electrochemical oxidation of catechol has been studied in the presence of ketamine as a drug in phosphate buffer solution mixed with ethanol using voltammetric techniques. The obtained results indicated that the o-quinone formed from electro-oxidation of catechol participated in a 1,4-Michael addition reaction to form the corresponding new 2-(2-chlorophenyl)-2-[(3,4-dihydroxyphenyl)(methyl)amino]cyclohexanone under ECE mechanism. The electro-organic synthesis has been successfully performed under mild condition in a divided cell in good yield.

Author information
  • Department of Chemistry, Faculty of Science, Imam Hossein University, Tehran, 16597, Iran

    M. Najafi

  • Khatam Al-Anbia University, Tehran, Iran

    M. M. Lajvardi

  • Department of Chemistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

    L. Youseftabar-Miri

  • Department of Chemistry, Semnan University, Semnan, Iran

    M. Ameri & O. Ghaderi

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