Highly Sensitive Nanostructured Electrochemical Sensor Based on Carbon Nanotubes-Pt Nanoparticles Paste Electrode for Simultaneous Determination of Levodopa and Tyramine

Mehdi Baghayeri Mehdi Baghayeri , Hadi Beitollahi Hadi Beitollahi , Ali Akbari Ali Akbari , Samaneh Farhadi Samaneh Farhadi
Российский электрохимический журнал
Abstract / Full Text

A multicomponent electrochemical sensor, with two nanometer-scale components in sensing matrix/electrode, was used to simultaneous determination of levodopa (LD) and tyramine (TR) in pharmaceutical and diet samples. Multiwall carbon nanotubes (MWCNTs) were used as carbonaceous materials in the electrode construction. 5-amino-3',4'-dimethoxy-biphenyl-2-ol (5ADMB) was used as electron mediator and Pt nanoparticles (nPt) as a catalyst. The 5ADMB catalyzes the oxidation of LD to the corresponding catecholamine, which is electrochemically reduced back to LD. Preparation of this electrode was very simple and modified electrode showed good properties at electrocatalytic oxidization of LD and TR. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of LD and TR has been explored at the modified electrode. Differential pulse voltammetry peak currents of LD and TR increased linearly with their concentrations at the ranges of 0.50–100.0 μM and 0.60–100.0 μM, respectively. Also, the detection limits for LD and TR were 0.31 and 0.52 μM, respectively. The electrode exhibited an efficient catalytic response with good reproducibility and stability.

Author information
  • Department of Chemistry, Faculty of Science, Hakim Sabzevari University, P.O. Box 397, Sabzevar, Iran

    Mehdi Baghayeri & Samaneh Farhadi

  • Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

    Hadi Beitollahi

  • Department of Chemistry, University of Jiroft, Jiroft, Iran

    Ali Akbari

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