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Статья
2020

Synthesis and Cytotoxicity of Quinazolin-4(3H)-one Based Peptides


P. ShankaraiahP. Shankaraiah, A. K. D. BhavaniA. K. D. Bhavani, A. Kishore KumarA. Kishore Kumar, K. RamakrishnaK. Ramakrishna
Российский журнал общей химии
https://doi.org/10.1134/S1070363220040246
Abstract / Full Text

A novel series of quinazolin-4(3H)-one derivatives has been synthesized in high yields using the multicomponent Ugi reaction and characterized by IR, NMR and mass spectral data. The products have been tested for their cytotoxic activity against HeLa cells. Two tested compounds have shown potent activity compared to standard drug Doxorubicin. The in silico docking studies of the compounds against quinone reductase-2 (4ZVM) enzyme have also supported their activity.

Author information
  • Department of Chemistry, University College of Science, Osmania University, 500007, Hyderabad, IndiaP. Shankaraiah, A. K. D. Bhavani & K. Ramakrishna
  • Department of Humanities and Sciences, Vardhaman College of Engineering, Shamshabad, Hyderabad, 501218, Telangana, IndiaP. Shankaraiah & A. Kishore Kumar
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