Статья
2021
Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles
N. A. Pakholka, V. L. Abramenko, V. V. Dotsenko, N. A. Aksenov, I. V. Aksenova, S. G. Krivokolysko
Российский журнал общей химии
https://doi.org/10.1134/S1070363221030038
Abstract / Full Text
Bromination of (2E)-3-aryl(hetaryl)-2-[4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles proceeds regioselectively at the C5 atom of the thiazole ring with the formation of new (2E)-3-aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles. The latter were alternatively obtained by the reaction of aldehydes, cyanothioacetamide, α-bromoketones and bromine in the presence of triethylamine in DMF. Structure of the key compounds was confirmed using 2D NMR spectroscopy and single crystal X-ray diffraction analysis.
Author information
- Laboratory ChemEx, V. Dal Lugansk State University, 91034, Lugansk, UkraineN. A. Pakholka, V. L. Abramenko & S. G. Krivokolysko
- Kuban State University, 350040, Krasnodar, RussiaV. V. Dotsenko
- North Caucasus Federal University, 355009, Stavropol, RussiaV. V. Dotsenko, N. A. Aksenov & I. V. Aksenova
- St. Luke Lugansk State Medical University, 91045, Lugansk, UkraineS. G. Krivokolysko
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