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Статья
2021

New metal complexes of citrus pectin with magnesium ions: synthesis, properties, and immunomodulatory activity


S. T. MinzanovaS. T. Minzanova, V. F. MironovV. F. Mironov, A. V. KhabibullinaA. V. Khabibullina, D. M. ArkhipovaD. M. Arkhipova, L. G. MironovaL. G. Mironova, A. V. NemtarevA. V. Nemtarev, A. B. VyshtakalyukA. B. Vyshtakalyuk, E. V. ChekunkovE. V. Chekunkov, K. V. KholinK. V. Kholin, I. R. NizameevI. R. Nizameev, V. A. MilyukovV. A. Milyukov
Российский химический вестник
https://doi.org/10.1007/s11172-021-3105-7
Abstract / Full Text

Magnesium complexes based on sodium polygalacturonate and pectinate were prepared and characterized. The conditions of complex formation were optimized and the immunomodulatory activity of the complexes was studied in vivo for the first time. The pectin complexes with magnesium ions decrease the immunosuppressive effect of the cyclophosphamide cytostatic, associated with a decrease in the number of immune cells in the blood (leukopenia) after administration of cyclophosphamide, and promote restoration of the white blood cell count in blood and the ratio of their subpopulations, i.e., the complexes exhibit immunomodulatory properties.

Author information
  • A. E. Arbuzov Institute of Organic and Physical Chemistry, Federal State Budgetary Institution of Science, “Kazan Scientific Center of Russian Academy of Sciences”, 8 ul. Arbusova, 420088, Kazan, Russian FederationS. T. Minzanova, V. F. Mironov, A. V. Khabibullina, D. M. Arkhipova, L. G. Mironova, A. V. Nemtarev, A. B. Vyshtakalyuk, E. V. Chekunkov, K. V. Kholin, I. R. Nizameev & V. A. Milyukov
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