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Статья
2021

Synthesis and Regiospecific Bromination of (2E,4E)-5-Aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitrile


N. A. PakholkaN. A. Pakholka, V. V. DotsenkoV. V. Dotsenko, B. S. KrivokolyskoB. S. Krivokolysko, K. A. FrolovK. A. Frolov, N. A. AksenovN. A. Aksenov, I. V. AksenovaI. V. Aksenova, S. V. ShcherbakovS. V. Shcherbakov, S. N. OvcharovS. N. Ovcharov, S. G. KrivokolyskoS. G. Krivokolysko
Российский журнал общей химии
https://doi.org/10.1134/S1070363221040058
Abstract / Full Text

The reaction of (2E,4E)-5-phenyl-2-cyano-2,4-pentadienethioamide or (E)-3-(2-nitrophenyl)acrolein and cyanothioacetamide with α-bromoketones afforded new (2E,4E)-5-aryl-2-(4-arylthiazol-2-yl)penta-2,4-dienenitriles. Direct bromination of the latter by the action of bromine in DMF proceeded regiospecifically at the C5 position of the thiazole ring without affecting the diene system and leads to the formation of new series of (2E,4E)-5-aryl-2-(5-bromo-4-arylthiazol-2-yl)penta-2,4-dienenitriles.

Author information
  • Laboratory “KhimEx”, V. Dahl Lugansk State University, 91034, Lugansk, UkraineN. A. Pakholka, K. A. Frolov & S. G. Krivokolysko
  • Kuban State University, 350040, Krasnodar, RussiaV. V. Dotsenko
  • North Caucasus Federal University, 355009, Stavropol, RussiaV. V. Dotsenko, N. A. Aksenov, I. V. Aksenova, S. V. Shcherbakov & S. N. Ovcharov
  • St. Luke Lugansk State Medical University, 91045, Lugansk, UkraineB. S. Krivokolysko, K. A. Frolov & S. G. Krivokolysko
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