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Статья
2020

Effect of Structure of 1-Substituted Isatins on Direction of Their Reactions with Some Acetohydrazide Ammonium Derivatives


A. V. BogdanovA. V. Bogdanov, A. D. VoloshinaA. D. Voloshina, A. S. SapunovaA. S. Sapunova, N. V. KulikN. V. Kulik, V. F. MironovV. F. Mironov
Российский журнал общей химии
https://doi.org/10.1134/S1070363220090029
Abstract / Full Text

The reaction of 1-acylisatins with Girard’s reagent T proceeds with elimination of the acyl substituent and the formation of isatin-3-hydrazone with a quaternary nitrogen atom in the side chain. Depending on the structure of the substituent in position 1, 1-(aminomethyl)isatins reacted with the Girard’s reagent T to form hydrazones either with the elimination of the aminomethyl substituent or with its retention. Isatin derivatives containing no substituents in the aromatic fragment exhibit moderate activity against gram-positive bacteria S. aureus 209p and B. cereus 8035. Low hemotoxicity of the obtained compounds was revealed.

Author information
  • A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”, 420088, Kazan, RussiaA. V. Bogdanov, A. D. Voloshina, A. S. Sapunova, N. V. Kulik & V. F. Mironov
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