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Статья
2022

Hydrophilic sulfur-containing antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate as a modulator of the activity of antitumor cytostatics and their combinations with a NO donor


T. N. BogatyrenkoT. N. Bogatyrenko, N. V. KandalintsevaN. V. Kandalintseva, T. E. SashenkovaT. E. Sashenkova, U. Yu. AllayarovaU. Yu. Allayarova, D. V. MishchenkoD. V. Mishchenko
Российский химический вестник
https://doi.org/10.1007/s11172-022-3442-1
Abstract / Full Text

The interaction of a combination of a sulfur-containing phenolic antioxidant sodium 3-(3-tert-butyl-4-hydroxyphenyl)propylthiosulfate (TS-13) with a nitric oxide donor (NaNO2) and two antitumor cytostatics, cisplatin and doxorubicin, was studied in vivo using a model of P-388 murine leukemia of BDF1 mice. It has been shown that the type of cytostatics used determines the efficiency of chemotherapy. Depending on this, the antioxidant TS-13 can both enhance and reduce the antitumor effect. The use of TS-13 and a nitric oxide donor with different cytostatics and different modes of drug administration modulates their activity in different ways, namely, from increasing survival to inhibition of survival.

Author information
  • Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian FederationT. N. Bogatyrenko, T. E. Sashenkova, U. Yu. Allayarova & D. V. Mishchenko
  • Novosibirsk State Pedagogical University, 28 ul. Vilyuyskaya, 630126, Novosibirsk, Russian FederationN. V. Kandalintseva
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