In the present work, the synthesis of SnO2–Zn2SnO4 nanocomposite was fulfilled according to solid-state technique followed by calcination. The SnO2–Zn2SnO4 nanocomposites were specified by X-ray diffraction and scanning electron microscopy. Then, oxidation response of cabergoline (Cab) was investigated on the surface of SnO2–Zn2SnO4 modified carbon paste electrode (SnO2–Zn2SnO4/CPE), exhibiting a well-defined single oxidation peak at +0.84 V vs. Ag/AgCl, NaCl (3 M) in an irreversible process. In oxidation reaction of Cab, equal number of protons and electrons are participated and the oxidation reaction rate is controlled by an adsorption step. The calibration curve from differential pulse voltammetry showed linearity in the concentration range of 3.0 to 155.0 µM (R2 = 0.9936) and detection limit was calculated to be 0.01 µM. The analysis results certified that SnO2–Zn2SnO4/CPE possess considerable potential to detect Cab in biological fluids.