Статья
2020
New Structural Modifications of Cotarnine Alkaloid Derivatives: Cotarnone and Dihydrocotarnine
V. G. Kartsev, A. A. Zubenko, L. N. Divaeva, A. S. Morkovnik, T. K. Baryshnikova, V. Z. Shirinian
Российский журнал общей химии
https://doi.org/10.1134/S1070363220020127
Abstract / Full Text
Simplest derivatives of the cotarnine alkaloid, like cotarnone and 1,2-dihydrocotarnine, undergo electrophilic Einhorn acylamidomethylation (with 60–95% yield) and sulfochlorination with chlorosulfonic acid at position 5. At the same time cotarnone and its derivatives undergo additional O-protodemethylation. Using these and some other reactions, we synthesized a number of previously unknown derivatives of two substrates with 5-chloroacetamidomethyl, 5-arylaminomethyl, 5-aminomethyl and 5-sulfamide groups.
Author information
- InterBioScreen Ltd, 142432, Chernogolovka, RussiaV. G. Kartsev
- North Caucasian Zonal Veterinary Research Institute, Federal Rostov Agrarian Scientific Center, 346406, Novocherkassk, RussiaA. A. Zubenko
- Institute of Physical and Organic Chemistry of Southern Federal University, 344090, Rostov-on-Don, RussiaL. N. Divaeva & A. S. Morkovnik
- N.D. Zelinsky Institute of Organic Chemistry of Russian Academy of Sciences, 119991, Moscow, RussiaT. K. Baryshnikova & V. Z. Shirinian
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