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Статья
2022

Efficient Synthesis of Deuterium-Labelled Ganciclovir-d5 and Its Prodrug Valganciclovir-d5


R. ParameshwarR. Parameshwar, K. DurgaprasadK. Durgaprasad, M. PrathapM. Prathap
Российский журнал общей химии
https://doi.org/10.1134/S1070363222040168
Abstract / Full Text

An efficient protocol has been developed for the synthesis of deuterium labeled ganciclovir-d5, a potent anti-cytomegalovirus agent and its prodrug, valganciclovir-d5, by using inexpensive and commercially available glycerol-d5 reagent. Structure and purity of the synthesized compounds are confirmed by 1H NMR and MS spectral data. The deuterium incorporation in ganciclovir-d5 and its prodrug was >98% which resembles the reported earlier deuterium abundance in the labeled starting material (glycerol-d5, >98% atom D). The results indicate that there is no loss of deuterium by exchange in the course of synthesis. Hence, these molecules can be used as standards in bio-analytical studies.

Author information
  • Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University, Gwalior, 474020, Madhya Pradesh, IndiaR. Parameshwar & M. Prathap
  • Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, 781026, Assam, IndiaK. Durgaprasad
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