Examples



mdbootstrap.com



 
Статья
2020

Microwave Assisted Synthesis and Antimicrobial Activity of Novel Pyrrolidine Derivatives


K. SreekanthK. Sreekanth, Anjali JhaAnjali Jha
Российский журнал общей химии
https://doi.org/10.1134/S107036322001020X
Abstract / Full Text

Microwave assisted synthesis of 1-acetyl-2-benzylpyrrolidine-2-carboxylic acid and its derivatives has been developed with highly encouraging yields. 2-Benzyl-tert-butylpyrrolidine-1,2-dicarboxylate is used as an initial compound in the four steps synthesis of the target compounds. Structures of the products 5a–5h have been confirmed by spectroscopic methods. According to antimicrobial tests 1-acetyl-2-benzylpyrrolidine-2-carboxamide 5c is determined to be the most potent product.

Author information
  • Department of Chemistry, GIS, GITAM, Rushikonda, Visakhapatnam, 530045, IndiaK. Sreekanth & Anjali Jha
References
  1. Lokhande, T.N., Bobade, A.S., and Khadse, B.G., Indian Drugs, 2003, vol. 40, no. 3, p. 147.
  2. Hensler, M.E., Bernstein, G., Nizet, V., and Nefzi, A., Bioorg. Med. Chem. Lett., 2006, vol. 16, p. 5073. https://doi.org/10.1016/j.bmcl.2006.07.037
  3. Li, X., Li, Y., and Xu, W., Bioorg. Med. Chem., 2005, vol. 14, p. 1287. https://doi.org/10.1016/j.bmc.2005.09.031
  4. Imamura, S., Ishihara, Y., Hattori, T., Kurasawa, O., Matsushita, Y., and Sugihara, Y., Chem. Pharm. Bull., 2004, vol. 52, no. 1, p. 63. https://doi.org/10.1248/cpb.52.63
  5. National Committee for Clinical and Laboratory Standards, Method for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, 4 ed., NCCLS, Villanova, Italy, 1997 Document M 100-S7. S100–S157.
  6. Arshad, M., Russ. J Gen. Chem., 2018, vol. 88, no. 9, p. 1886. https://doi.org/10.1134/S1070363218090207