Electrosynthesis of Tetrazolylacetic Acid

B. V. Lyalin , V. A. Petrosyan
Российский электрохимический журнал
Abstract / Full Text

Regularities governing the oxidation of 1-(2-hydroxyethyl)tetrazole on a nickel hydroxide anode inan aqueous NaOH solution are studied. The optimum conditions for producing tetrazolylacetic acid while stillobtaining high yields of the target product (87%) are found; these are: calc = 0.5–0.75 M, cNaOH = 1 M,T=25°C, and janode = 16 mA cm–2. The presence of the chloride ion in 1-(2-hydroxyethyl)tetrazole is shown tocause rapid destruction of the Ni anode. The oxidation of 1-(2-hydroxyethyl)tetrazole by Ni(OH)3 that has beenelectrochemically generated in an aqueous solution is explored. The yield of the target product is found todepend on the duration and temperature of the reaction, reaching 85% under optimum conditions ( = 5 h,T=30°C).