Статья
2020
Methyl (S)-(5-methylidene-4-oxocyclopent-2-en-1-yl)acetate as a readily available pharmacologically important subunit of cross-conjugated cyclopentenone prostaglandins
N. S. Vostrikov, Z. R. Makaev, V. V. Zagitov, F. A. Lakhvich, F. S. Pashkovsky, M. S. Miftakhov
Российский химический вестник
https://doi.org/10.1007/s11172-020-2796-5
Abstract / Full Text
A short and convenient synthesis of exomethylidenecyclopentenone core of cyclopentenone prostaglandins (+)−3 from (−) Corey lactone diol is described. The chiral 5-phenylthio and 5-phenylsulfonyl derivatives of exomethylidenecyclopentenone were obtained and their cytotoxic properties were studied in comparison with the synthesized earlier ethylthio and ethylsulfonyl derivatives of (±)−3, announced as its more stable bioisosteres.
Author information
- Ufa Institute of Chemistry, Ufa Federal Scientific Center of the Russian Academy of Sciences, 71 prosp. Oktyabrya, 450054, Ufa, Russian FederationN. S. Vostrikov, Z. R. Makaev, V. V. Zagitov & M. S. Miftakhov
- Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk, BelarusF. A. Lakhvich & F. S. Pashkovsky
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