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Article
2018

Electrochemical Synthesis of 2-(2-Chlorophenyl)-2-[(3,4- dihydroxyphenyl)(methyl)amino]cyclohexanone


M. NajafiM. Najafi, M. M. LajvardiM. M. Lajvardi, L. Youseftabar-MiriL. Youseftabar-Miri, M. AmeriM. Ameri, O. GhaderiO. Ghaderi
Russian Journal of Electrochemistry
https://doi.org/10.1134/S1023193518130311
Abstract / Full Text

Electrochemical oxidation of catechol has been studied in the presence of ketamine as a drug in phosphate buffer solution mixed with ethanol using voltammetric techniques. The obtained results indicated that the o-quinone formed from electro-oxidation of catechol participated in a 1,4-Michael addition reaction to form the corresponding new 2-(2-chlorophenyl)-2-[(3,4-dihydroxyphenyl)(methyl)amino]cyclohexanone under ECE mechanism. The electro-organic synthesis has been successfully performed under mild condition in a divided cell in good yield.

Author information
  • Department of Chemistry, Faculty of Science, Imam Hossein University, Tehran, 16597, IranM. Najafi
  • Khatam Al-Anbia University, Tehran, IranM. M. Lajvardi
  • Department of Chemistry, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, IranL. Youseftabar-Miri
  • Department of Chemistry, Semnan University, Semnan, IranM. Ameri & O. Ghaderi
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