Development of operation algorithms and proper design of proton exchange membrane fuel cell stacks for effective operation at various external climatic conditions are the main issues need to be addressed for the widespread implementation of this technology. The main challenge for northern regions is to provide a rapid start-up procedure of stack from low temperatures to operation conditions without any damage. In this work, we studied the features of low-temperature operation and proposed an effective low-temperature start-up algorithm of low power (up to 100 W) open-air cathode stack with active air-cooling technology.