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Article
2021

A Novel Electrochemical Sensor Based on Reduced Graphene Oxide–TiO2 Nanocomposites with High Selectivity for the Determination of Hydroxychloroquine


 Huilan Zhang Huilan Zhang, Lu ChengLu Cheng, Hongyuan ShangHongyuan Shang, Wen ZhangWen Zhang, Aiping ZhangAiping Zhang
Russian Journal of Electrochemistry
https://doi.org/10.1134/S1023193521080152
Abstract / Full Text

A simply sensitive sensor based on a reduced graphene oxide–TiO2 nanocomposite modified glassy carbon electrode (RGO–TiO2/GCE) was developed for the electrochemical determination of an antimalarial drug, hydroxychloroquine (HCQ). The modified electrode was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Electrochemical test showed that the RGO–TiO2 electrode had stronger electrochemical activity and higher effective real surface area than that of TiO2 electrode and bare electrode. The electrochemical response of RGO–TiO2 nanocomposite modified electrode toward HCQ oxidation was studied by CV, chronoamperometry (CHA), chronocoulometry (CHC) and square-wave voltammetry (SWV). Interestingly, RGO–TiO2/GCE indicated an excellent electrocatalytic activity for HCQ. Under the optimal experimental conditions, a linear relationship between the peak current and the concentration was obtained, ranging from 0.25 to 500 μM, with the detection limit (S/N = 3) of 12.5 nM and quantification limit (S/N = 10) of 0.97 μM. Furthermore, the proposed sensor was successfully applied to the determination of HCQ in pharmaceutical (tablets) samples. In summary, the developed sensor was low cost and efficient, making it potentially attractive for practical sample analysis application of HCQ.

Author information
  • College of Pharmacy, Shanxi Medical University, 030001, Shanxi, Taiyuan, P. R. China Huilan Zhang, Lu Cheng, Wen Zhang & Aiping Zhang
  • College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123, Suzhou, PR ChinaHongyuan Shang
References
  1. Mashhadizadeh, M.H. and Akbarian, M., Voltammetric determination of some anti-malarial drugs using a carbon paste electrode modified with Cu(OH)2 nano-wire, Talanta, 2009, vol. 78, p. 1440.
  2. Pal, A., Pawar, A., Goswami, K., Sharmae, P., and Prasad, R., Hydroxychloroquine and Covid-19: a cellular and molecular biology based update, Indian J. Clin. Biochem., 2020, vol. 35, no. 3, pp. 274–284.
  3. Assalie, N.A., Durcan, R., and Durcan, L., Hydroxychloroquine-induced erythema multiforme, J. Clin. Rheumatol., 2017, vol. 23, p. 127.
  4. Merino, A.C., Molina, C.Z., and Suárez, P.D., Hydroxychloroquine, a potentially lethal drug, Med. Intensiva, 2017, vol. 41, p. 257.
  5. Devnani, H., Satsangee, S.P., and Jain, R., A novel graphene-chitosan-Bi2O3 nanocomposite modified sensor for sensitive and selective electrochemical determination of a monoamine neurotransmitter epinephrine, Ionics, 2016, vol. 22, p. 943.
  6. Khalil, M.M., Issa, Y., and El Sayed, G.A., Modified carbon paste and polymeric membrane electrodes for determination of hydroxychloroquine sulfate in pharmaceutical preparations and human urine, RSC Adv., 2015, vol. 5, p. 83657.
  7. Qu, Y., Noe, G., and Breaud, A.R., Development and validation of a clinical HPLC method for the quantification of hydroxychloroquine and its metabolites in whole blood, Future Sci. OA, vol. 1, p. fso.15.24.
  8. Singh, A., Singh, C.L., and Gupta, R., Development and validation of reversed-phase high performance liquid chromatographic method for hydroxychloroquine sulphate, Indian J. Pharm. Sci., 2015, vol. 77, p. 586.
  9. Oliveira, A.R.M.D., Cardoso, C.D., and Bonato, P.S., Stereoselective determination of hydroxychloroquine and its metabolites in human urine by liquid-phase microextraction and CE, Electrophoresis, 2007, vol. 28, p. 1081.
  10. Wang, L.Z., Ong, Y.L., and Chin, T.M., Method development and validation for rapid quantification of hydroxychloroquine in human blood using liquid chromatography-tandem mass spectrometry, J. Pharm. Biomed., 2012, vol. 61, p. 8.
  11. Füzéry, A.K., Breaud, A.R., and Emezienna, N., A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry, Clin. Chim. Acta, 2013, vol. 42, p. 79.
  12. Deroco, P.B., Vicentini, F.C., and Oliveira, G.G., Square-wave voltammetric determination of hydroxychloroquine in pharmaceutical and synthetic urine samples using a cathodically pretreated boron-doped diamond electrode, Electroanal. Chem., 2014, vol. 719, p. 19.
  13. Ghoreishi, S.M., Attaran, A.M., and Amin, A.M., Multiwall carbon nanotube-modified electrode as a nanosensor for electrochemical studies and stripping voltammetric determination of an antimalarial drug, RSC Adv., 2015, vol. 5, p. 14407.
  14. Khoobi, A., Ghoreishi, S.M., and Behpour, M., Design and evaluation of a highly sensitive nanostructure-based surface modification of glassy carbon electrode for electrochemical studies of hydroxychloroquine in the presence of acetaminophen, Colloids Surf. B, 2014, vol. 123, p. 648.
  15. Khoobi, A., Ghoreishi, S.M., and Behpour, M., Sensitive and selective determination of hydroxychloroquine in the presence of uric acid using anew nanostructure self-assembled monolayer modified electrode: optimization by multivariate data analysis, Analyst, 2014, vol. 139, p. 4064.
  16. Wanag, A., Rokicka, P., and Wrobel, R.J., Antibacterial properties of TiO2 modified with reduced grapheneoxide, Ecotoxicol. Environ. Saf., 2018, vol. 147, p. 788.
  17. Wang, M., Zhai, S., and Ye, Z., An electrochemical aptasensor based on a TiO2/three-dimensional reduced graphene oxide/PPy nanocomposite for the sensitive detection of lysozyme, Dalton. T, 2015, vol. 44, p. 6473.
  18. Li, Y., Gu, Y., and Zheng, B., A novel electrochemical biomimetic sensor based on poly (Cu-AMT) with reduced graphene oxide for ultrasensitive detection of dopamine, Talanta, 2017, vol. 162, p. 80.
  19. Manna, B. and Raj, C.R., Nanostructured sulfur-doped porous reduced graphene oxide for the ultrasensitive electrochemical detection and efficient removal of Hg(II), ACS. Sustainability Chem. Eng., 2018, vol. 6, p. 6175.
  20. Kim, T.W. and Park, S.J., Synthesis of reduced graphene oxide/thorn-like titanium dioxide nanofiber aerogels with enhanced electrochemical performance for supercapacitor, J. Colloid. Interface Sci., 2017, vol. 486, p. 287.
  21. Gülercan, D., Gergin, İ., and Sarac, A.S., Preparation and electrochemical performances of graphene oxide/PEDOT and reduced graphene oxide/PEDOT nanofibers and nanocomposites, Fiber. Polym., 2018, vol. 19, p. 2178.
  22. Shang, H.Y., Ma, M., and Zhang, A.P., Self-assembled reduced graphene oxide-TiO2 thin film for the enhanced photocatalytic reduction of Cr(VI) under simulated solar irradiation, J. Nanosci. Nanotechnol., 2019, vol. 19, p. 3376.
  23. Kang, X., Wang, J., and Wu, H., A graphene-based electrochemical sensor for sensitive detection of paracetamol, Talanta, 2010, vol. 81, p. 754.
  24. Juana, R., Gregorio, C., and Lizcano, I., Electrochemical sensor for leukemia drug imatinib determination in urine by adsorptive striping square wave voltammetry using modified screen-printed electrodes, Electrochim. Acta, 2018, vol. 269, p. 668.
  25. Shereen, M.A. and Amany, M.F., Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug, RSC Adv., 2017, vol. 7, p. 1118.
  26. Ferrari, A.G.M., Foster, C.W., Kelly, P.J., Brownson, D.A.C., and Banks, C.E., Determination of the electrochemical area of screen-printed electrochemical sensing platforms, Biosensors, 2018, vol. 8, p. 53.
  27. Deroco, P.B., Oliveira, G.G., and Rocha-Filho, R.C., Square-wave voltammetric determination of hydroxychloroquine in pharmaceutical and synthetic urine samples using a cathodically pretreated boron-doped diamond electrode, Electroanal. Chem., 2014, vol. 719, p. 19.