Determination of Propranolol at a Carbon Paste Electrode Modified with Magnetite–Graphene Oxide in Combination with Presence of Sodium Dodecyl Sulfate

 Hediyeh Bagheri Ladmakhi Hediyeh Bagheri Ladmakhi , Shahla Fathi Shahla Fathi , Fereshteh Chekin Fereshteh Chekin , Jahan Bakhsh Raoof Jahan Bakhsh Raoof
Russian Journal of Electrochemistry
Abstract / Full Text

In this study, a new electrochemical sensor based on magnetite graphene oxide/modified carbon paste electrode (Fe3O4–GO/CPE) was applied for determination of a cardiovascular drug, propranolol (PRO) in solution containing sodium dodecyl sulfate (SDS) as a surfactant. Results show that combination of modified electrode with surfactant addition, considerably increased electroanalytical signal for PRO determination and resulted to sensitive detection of PRO with linear range of 10–1500 μM, limit of detection of 4.5 μM and sensitivity of 166 µA mM–1. Applicability of this analytical method for detection of PRO in pharmaceutical formulations was studied and acceptable results obtained.

Author information
  • Department of Chemistry, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran

    Hediyeh Bagheri Ladmakhi, Shahla Fathi & Fereshteh Chekin

  • Electroanalytical Chemistry Research Laboratory, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

    Jahan Bakhsh Raoof

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